Give your little one some practice building multiplication skills with this multiply 1000 and 2-digit numbers worksheet. Students use the pattern of zeros when they are asked to multiply numbers by 10, 100, or their multiples. They apply the same concept to find the missing number in multiply 1000 and 2-digit numbers worksheet. In each problem, the numbers are laid out in the horizontal format. Students should try to use different strategies involving composing and decomposing numbers to solve these problems. This will help them develop flexibility and fluency.